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KMID : 0351619740150010243
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Kyungpook Medical Journal
1974 Volume.15 No. 1 p.243 ~ p.252
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Effects of Steroid on the Flow, Acid Phosphatase, Protein and Its Fraction of Thoracic Duct Lymph in Hemorrhagic Shock
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Abstract
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In hemorrhage, the return of lymph to general circulation through the thoracic duct has been shown t:o be an important step in blood volume restoration a.nd cardiovascular compensation and proteolytic enzymes released from lysescmes during shock has been kro~;-n to be deleterious to tissues a.nd cells.
Ideally, a substance which increases thoracic duct lymph flow without increased lysosomal enzyme content should have a therapeutic merit in the treatment of shock.
With use of glucocortieoids, an increased lymph flow migr~t be expected, because glucucorticoids have a certain hemodynamic mechanism. At the same time, since ate: olds stabilize iysosoma membrane, an increased release of lyscsemal enzyme might be ,avoided with their use.
However, the effect of steroids on thoracic duct lymph flow and lysosomal enzy.re content heal not been extensively investigated.
The author studied the effect of steroid on flow, protein content and ac?d phosphatase activities of thoracic duct lymph in canine hemorrhagic shock of 40mmH;; blood pressure and the follwing results ~ve~re obtained.
The administration of dexamethasone 30 minutes after onset e~´ shock slightly increased the flo~.v of thoracic lymph, whereas a marked decrease of lymph flow was observed in the non-treated dog.
In concentration of protein and its fraction of serum and lymph, no difference between steroid treated and non-treated dogs was noted.
The accumulation of serum acid phosphatase in steroid administered dog was considerably lower than that of non-treated one. Lymphatic acid phosphatase content was similarly affected.
As a result, it was postulated that the administration of glucocorticoid might be effective in the treatment of hemorrhagic shock.
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